Pdf amelioration of ionizing radiation induced lipid peroxidation in. We report here that ferroptosis, a form of nonapoptotic cell death driven by lipid peroxidation, is partly responsible for radiationinduced cancer cell death. Vitamin e and vitamin c completely protected against uvbradiationinduced lipid peroxidation p pdf 51 k pdf plus 97 k citing articles. Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of dna repair and inhibition of apoptosis. Request pdf radiation induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. Effects of calmodulin antagonists on radiationinduced. Pdf antioxidant capabilities of scoparone, the component of artemisia scoparia and other medicinal plants, against lipid peroxidation induced by. When the microsomes are irradiated in the presence of n20, the resulting lipid peroxidation is predominantly due to hydroxyl radicals. Topical antioxidant vitamins c and e prevent uvbradiation. Lipid peroxidation was found to increase with increase in concentrations of ferrous ions fig.
Pdf influence of ferulic acid on gammaradiation induced. Radiation induced lipid peroxidation in liposomes sciencedirect. Inhibition of radiation induced lipid peroxidation by tetrahydrocurcumin. Modulation of radiation induced lipid peroxidation by phospholipase. Ionizing radiation is classified as either electromagnetic or particulate. Lipid peroxidation is shown to have importance in understanding the modifications of radiation effects.
Selenium represents an adjuvant that selectively sensitizes cancer cells to these treatments modalities, potentially by inducing lipid peroxidation. Radiationinduced lipid peroxidation triggers ferroptosis and. Radiation induced peroxidative damage semantic scholar. Pdf protective effect of moringa oleifera leaf extract mole against radiation induced lipid peroxidation has been investigated.
Swiss albino mice were administered mole 300 mgkg of body weight for 15 consecutive days before exposing them to a single dose of 5 gy of 60 co. Vitamin e and vitamin c completely protected against uvb radiation induced lipid peroxidation p induced a vitamin e consumption of up to 100% in the stratum corneum and viable epidermis, and a vitamin c consumption of only 21% in the stratum corneum. Antioxidant activity of capsaicin on radiationinduced. We have studied the effect of ferrous ions on radiation induced lipid peroxidation. Inhibition of radiationinduced lipid peroxidation by. The antioxidant has significant time and concentrationdependent inhibitory effect on lipid peroxidation induced by rradiation. Radiationinduced lipid peroxidation triggers ferroptosis and synergizes. Request pdf radiationinduced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. Pdf protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated. Amelioration of ionizing radiation induced lipid peroxidation. Protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated. The present study evaluated the hepatoprotective effect of aqueous ethanolic moringa oleifera leaf extract mole against radiationinduced oxidative stress, which is assessed in terms of inflammation and lipid peroxidation.
Leaf extract of moringa oleifera prevents ionizing. Pdf scoparone inhibits ultraviolet radiationinduced lipid. Capsaicin is the major capsaicinoid in chili peppers and is widely used as a spice. Additional methods and supplemental figures and tables pdf. Ionizing radiationinduced metabolic oxidative stress and. Methylseleninic acid induces lipid peroxidation and radiation.
It is the interaction of these radiationinduced free radicals with important biomolecules within the cell that is the basis of the cellular sensitivity to radiation. Efforts are made to show similarities between radiolytic and. Lipid peroxidation after ionizing irradiation leads to apoptosis and. Radiationinduced lipid peroxidation triggers ferroptosis. Curcumin was incorporated into microsomes during ultracentrifugation. Pdf inhibition of radiationinduced lipid peroxidation. Radiation induced peroxidation and fragmentation of lipids in a model membrane.
Ionizing radiation track structure and the nature of induced biological effects. The ability of curcumin, a natural antioxidant from turmeric, to inhibit radiationinduced lipid peroxidation in rat liver microsomes was examined. Calmodulin antagonists also decreased the cytochrome p450 content of microsomes. These results suggest that ferroptosis and lipid peroxidation contribute to radiationinduced cell death in ht1080 cells, and that this ferroptotic cell death can be enhanced by the addition of otherwise sublethal concentrations of ike or rsl3.
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